However, the small size of these trials and the consistency of the findings in the other eight larger trials suggest the missing data are unlikely to have substantially changed the results.
Finally, it was demonstrated previously, that the main cause of the variability in pain trials might be random chance associated with the relatively small size of the trial group [ 29].
However, the trial design limits generalizing these findings to a larger population, given the small size of the trial, the initial high dose of TRT used, and the unique mobility-limited population.
The small size of this trial, however, makes it difficult to draw conclusions, Bennett says.
None of the results presented reach statistical significance owing to the small size of the trial.
However, we acknowledge the small size of our trial as a limitation that may have prevented us to document small and sustained benefits.
While the authors did assess adrenal function at entry, the small size of the trial limited any meaningful subgroup analysis by cosyntropin responsiveness.
Owing to the small size of the trial and the relatively short study duration, no data monitoring committee will be established and no interim analyses will be conducted.
However, as albumin concentration declined with increasing degree of hepatic impairment, and due to the small size of this trial, it is not possible to state if the observed relationship is solely attributed to lower albumin concentrations or the other aspects of hepatic impairment.
Indeed, the large intrapatient variability of the erlotinib PK observed in this and other studies, as well as the relatively small size of the trial, may have contributed negatively, in part, to this observation (Soulieres et al, 2004; Herbst et al, 2005; Perez-Soler and Van Cutsem, 2007).
