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The prescreening step for a discriminating query will normally yield a small set of database candidate compounds that can quickly be scanned with VF2.
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These modifications have shown to increase the prediction performance for a small set of databases, in terms of a higher Pearson correlation coefficient and a lower root mean square prediction error between the auditory and the estimated MOS ratings.
The performance was tested on a relatively small set of queries and relatively small database, and it is possible that both are indeed strongly enriched by sequences with known domain composition.
However, they performed their analysis on the small set of complexes in the MIPS database [ 29], which show almost no overlap in their components (i.e. only 15 proteins are part of more than three MIPS complexes), as well as on the first generation of TAP data.
Even for this small set of compounds, several limitations in the rat database were apparent.
As a simple demonstration of this capability, we have generated a small set of 90 CHESS-encoded antidepressants containing selected information from two databases, as well as three different computational packages.
Although a small set of TFBSs has been experimentally validated as functional and recorded in reference databases, this probably represents an insignificant portion of the entire set of TFBSs in the human genome.
Starting with a small set of trusted correct PSMs and a set of incorrect PSMs from searching a decoy database, Percolator iteratively adjusts the learning model to fit the dataset by ranking high-confidence PSMs higher than decoy peptide matches.
Find a reasonably small set of stairs.
Do work with small sets of words.
PSI-BLAST is used in a first step to reduce a large sequence database to a smaller set of sequences showing a minimal amount of sequence similarity to the protein family of interest.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com