Sentence examples for small sequence variants from inspiring English sources

We used high-throughput sequence analysis in order to detect new genes that cause disease as we predicted that the greatest number of disease-causing mutations were small sequence variants that could be detected by this method.

To identify mutations caused by small sequence variants, sequence data were screened for SNPs and indels of <4 bases that had a read coverage of at least 40% of the average coverage for the specific strain, and occurred in one sample only, or in the case of the fus mutant, in two samples (pro23/fus and fus; Table 3).

In a small study, sequence variants in mitochondrial DNA (mtDNA) were investigated in specimens (no sputum) of lung, bladder and kidney cancer patients, and sputum from 12 cancer-free heavy smokers (Jakupciak et al, 2008).

Rather, there are several small branches with sequence variants.

According to Leitner et al. [ 9] very small populations of sequence variants can be detected with this method.

Unfortunately, this study analyzed a relatively small number of sequence variants in the DR4 apoptosis-related gene; hence, making it difficult to compare study findings.

Small clusters of sequence variants that coincide with the memory B-cell subset can be seen, further suggesting that selection for the clone members could be distinctive within the PB and memory B-cell subsets.

However, previous analyses have been based on relatively small sub-sets of sequence variants, and have not fully taken advantage of the rapid growing information on protein structure and function.

If many sequence variants with small effects control the trait, but only a small proportion of the SNP associations pass stringent thresholds, then relatively small perturbations in analysis inputs could cause substantial differences in the particular SNPs declared as significant.

125– 129 Others have reported common sequence variants of very small effect, including several in the human leukocyte antigen (HLA) region (6p).

Using isolates is advantageous because of very similar exposure to environmental factors and effects of small Ne – enrichment of some harmful sequence variants because of more pronounced random genetic drift, a higher level of consanguinity and overall genetic homogeneity.