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The initial results of a small scale phase II study suggested that exemestane, administered as primary treatment for locally advanced breast tumour, is capable of reducing tumour size in around 84% of patients (Miller and Dixon, 2002).
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The Food and Drug Administration maintained that so much was still unknown after the preliminary small-scale Phase 1 trial of a drug — the point at which the patients' group sought a right of access — that the drug could not responsibly be made available to patients.
A highly efficient and cost-effective method for comparison of adjuvants with a new antigen is to conduct multiple small-scale, phase 1, comparative studies in humans with a new antigen, using adjuvants previously found to be safe with other antigens in human trials.
In addition, we notice small-scale phase anomalies in both the dispersive and nondispersive signals, which are correlated with each other in terms of their locations.
The small-scale phase anomalies, however, remain in both Figs. 3a and 4a, whose locations are correlated with those of dispersive signals as noted below.
We also notice that the small-scale phase anomalies are more significant in the higher-order geomagnetic and bending effects; we do not apply any smoothing filters in Fig. 4.
The sum of the dispersive effects b d is shown in e. Regardless of whether we consider the effects of higher-order terms in the refractive index, we have identified small-scale phase anomalies on the order of ~ 5 km or less in both dispersive and nondispersive components at the same locations.
Several small-scale phase II studies of weekly-administered PTX reported response rates ranging from 16% to 24%(15, 17) for gastric cancer patients in a second-line setting (Table 5).
The small scale gap phase cycles would operate as nested dynamics within larger scale infrequent non-stand-replacing disturbance cycles that occur at landscape scale.
Via this pathway, impact among economic actors may be generated, although impacts may not have the aimed for high degree of dispersion in the current still small scale experimental phase.
It first considers liquid wall and liquid gas interaction at small scale via two-phase flow calculations using the VOF method.
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CEO of Professional Science Editing for Scientists @ prosciediting.com