This is particularly important in light of the results of the articles discussed above (Gutteridge and Thornton, 2005; Zavodszky and Kuhn, 2005) suggesting that small-scale changes are sufficient to account for side-chain flexibility in ligand binding.
What people struggle with is the idea that all that is required to explain the whole of life's diversity is these kind of small-scale changes being replicated enough times.
6. Think big and small New innovations or technologies with the potential to achieve huge impact can be attractive but consistent, small-scale change is equally important.
Furthermore, a lack of adherence to the notion of small-scale change is apparent and only 15% (7/47) reported the use of quantitative data at monthly or more frequent data intervals to inform progression of cycles.
Nonetheless, due to missing alternatives and as long as scale changes are small, traditional dimensionless scaling is still a viable route to successful fluidized bed reactor scaling.
From the results we can see that, when the scale changes are small, our method and Bicubic spline interpolation out-perform the rest of the methods.
Although the topics of improvement were different for these projects, the set up of the projects, working with the Plan-Do-Study-Act cycle and starting off with small scale changes first, is the same.
Determining the responsiveness of tools used to measure functional status in older adults is important because small scale changes may represent very large, clinically relevant, changes in quality of life.
She listed several types of evidence that she claimed to have influenced her "stronger acceptance" of evolution including "fossils," and "observations of small scale changes in things that are around today" which, she explained, "could lead to really big changes over billions of years".
This suggests that both large and small scale changes in the ribosome were still evolving after the domains diverged and then spreading among all of a domain's developing sub-branches [ 2].
Thus, in resource limited settings a good strategic starting point could be small scale changes that may markedly improve physicians' motivation and subsequently the quality of health care.
