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As expected, a small response mean was observed for the ESR (0.41).
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Regarding the responsiveness, in the study of Lamers et al. (2006) the responsiveness of the EQ-5D was small (standardised response mean: 0.47).
The larger the standardized response mean, the smaller the sample size needed to demonstrate a treatment effect.
SRM: Standardised Response Mean effect size (small: 0.20 0.49, medium: 0.50 0.79, large: ≥ 0.80) CES-D improved progressively at each follow-up except between 12 and 18 months after study entry.
SRM: Standardised Response Mean effect size (small: 0.20 0.49, medium: 0.50 0.79, large: ≥ 0.80) At six-month follow-up, the patients' average therapy outcome rating (numeric scale: 0 "no help at all", 10 "helped very well") was 7.54 ± 1.76; patient satisfaction with therapy (0 "very dissatisfied", 10 "very satisfied") was 7.92 ± 1.86.
AP = anteroposterior; CI = confidence interval; ICC = intraclass coefficient of correlation; JSN = joint space narrowing; JSW = joint space width; OA = osteoarthritis; SD = standard deviation; SDD = smallest detectable difference; SRM = standardized response mean; WOMAC = Western and Ontario MacMaster University.
The standardized response mean yielded somewhat smaller numbers than the effect size calculations but did not change the interpretation of the results.
The effect size was Hedge's g (a Standardised Response Mean estimator), which was corrected for small sample size bias.
The responsiveness to change was explored by calculation of the Standardized Response Mean (SRM) as the mean change divided by the SD of the change (definitions of SRM results: < 0.50 = small, 0.50 to 0.80 = moderate and > 0.80 = large responses).
c Standardized Response Mean.
†SRM: Standardized Response Mean.
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