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Locally advanced cancer of the uterine cervix covers a broad disease spectrum comprising primary tumours of >4 cm in size or FIGO stage >IIA and all local tumour relapses except the rare cases of small recurrences in a retained cervix.
Reader 1 detected all 7 small recurrences, both with standard MRI and after addition of DWI.
Residual disease and small recurrences frequently may be removed with in-office procedures, with particularly good results in nasoethmoid disease.
However, early detection by CT surveillance increases the diagnosis of small recurrences, making surgery feasible and less dangerous.
Therefore, we believe that incomplete resection or small recurrences per se should not indicate further management and agree that currently available imaging modalities may allow these tumors to be closely monitored.
In our study we indeed observed that DWI was helpful in such a case: the less experienced radiologist detected one of the small recurrences on MRI+DWI which he had overlooked before (Fig. 4).
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Open image in new window Fig. 27 Small recurrence not seen on MRI.
Reader 2 missed one small recurrence on standard MRI, but detected all 7 after addition of DWI (Fig. 4).
Thus, the finding of normal two SMN1 copy dosage significantly reduces the risk of being a carrier; however, there is still a residual risk of being a carrier and subsequently a small recurrence risk of future affected offspring for individuals with 2 SMN1 gene copies.
Early diagnosis of LTP is imperative because repeated treatment can still effectuate complete tumor clearance, especially for smaller recurrences.
In addition, patients positive for CRISP-3 have smaller recurrence-free probabilities after RP [ 97].
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CEO of Professional Science Editing for Scientists @ prosciediting.com