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Focusing on specific cell types, α- and δ-cell replication rates remained very low and of unclear significance at diabetes onset (Table 2), Indeed, the apparent small proliferation rate changes were evident using BrdU-labeling only, since such changes fall below the DNA-content technique's sensitivity threshold (Figure 1, inset).
Even bigger weakening of neuron reaction is observed as well as very small proliferation of glia cells and sporadically occurring changes in blood vessels.
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Both cell types produce smaller tumors with larger latency periods than untreated cells, indicative of smaller proliferation capacity.
In the group of animals exposed to dioxin action and additionally administered with TCP and ASA, evident reduction of immunohistochemical reaction of neurons was found compared to group IP, whereas smaller proliferation of glia cells and smaller changes in blood vessels were observed compared to those in group IPD.
Atypical small acinar proliferation and prostate intraepithelial neoplasia were excluded from the study.
A second morphological abnormality termed atypical small acinar proliferation has also been associated with increased risk of diagnosis with prostate cancer in subsequent biopsies.
These Th1 lymphocytes are responsible for the pathologic reactions in psoriatic skin leading to keratinocyte hyperproliferation, small vessel proliferation, and neutrophilic infiltration [ 16].
Biopsy of the graft exhibited a mesangial proliferative glomerulonephritis with a single small extracapillary proliferation and was positive for IgA by immunofluorescence.
Previous in vitro studies suggested that the intervertebral disc is a tissue with small cell proliferation and regeneration capacity both in annulus fibrosus and nucleus pulposus [ 44– 44].
Whenever high-grade prostate intraepithelial neoplasia (HG PIN) or atypical small acinar proliferation (ASAP) was detected, the biopsy was repeated within 3 6 mo.
A re-biopsy within 2 months was indicated if the primary histopathological diagnosis was prostatic intraepithelial neoplasia, atypical small acinar proliferation or unconfirmed suspicion of PC, or if the PSA level was ⩾10 ng ml−1.
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