Directed search algorithms, which identify directly a small number of sequences, have achieved some success in identifying sequences with desired structures and functions.
In the other approach, computational modeling is used to explore an astronomically large number of protein sequences to select a small number of sequences for experimental testing.
Clusters containing a small number of sequences: The MLE and MCE learning approaches need a large number of data points to give robust estimates of the model parameters.
Within marine sediments, most AOA sequences are unique to individual sampling locations, whereas a small number of sequences are evidently cosmopolitan in distribution.
In many cases when the query set contains only a small number of sequences or contains only highly related sequences, pseudocounts are added to normalize the distribution reflected in the scoring matrix.
This is particularly noteworthy considering the small number of sequences obtained in this study.
Other algorithms, such as [45], are only practical in analyses involving a small number of sequences.
The annotation also revealed a small number of sequences that are similar to plants.
Therefore, the analysis of the antibody response against the classified small number of sequences should be helpful to determine epitopes.
This could be explained by the small number of sequences for these subtypes in the Ottenby set (Table 2).
With a small number of sequences, there is a simple path to generating relatively high quality outputs for each of the above three desired results.
