Most of what we think we know about radicalisation is drawn from studies of a relatively small number of case studies.
A basic problem in studying tsunamis is that our knowledge of the sedimentological features of offshore tsunami deposits is limited to a small number of case studies (e.g., van den Bergh et al., 2003; Noda et al., 2007; Paris et al., 2010).
However, outcomes from a small number of case studies point to potential clinical benefit from dual endothelin receptor antagonism with bosentan in sarcoidosis-associated PH.
As part of the 'learning from the past' exercise in ABDC-10, these five sector-specific parallel sessions included the presentation of a small number of case studies of successful application of biotechnologies in developing countries, followed by a facilitated discussion.
Further, while the small number of case studies means that we cannot draw generalizable conclusions, the case study approach has allowed us to investigate the complex linkages between context, institute organization and financing, and policy influence.
While there is a burgeoning theoretical literature on barriers to adaptation (Adger et al. 2009; Biesbroek et al. 2010; Dow et al. 2013; Klein et al. 2014), it has been difficult to draw out general findings from the empirical evidence due to the small number of case studies, where context and scale are critical.
The few studies of diuretics and vertebral fracture have been limited by cases defined by self-report or administrative data, relatively small number of cases, study design that was not prospective, and lack of long-term follow-up with updated information on diuretic use.
Because first-in-man studies, by their nature, deal with single cases or a small number of cases, study design considerations might be largely irrelevant; but how they are reported is important.
The current case series carries weaknesses, the most predominant being its retrospective nature, the small number of cases studied and the inclusion of both congenital and neurogenic clubfeet.
This may be related to the fairly small number of cases studied.
