A wide variety of CHM-causing mutations include small deletions, nonsense mutations, missense mutations, frame shifts, splice site defects, retrotransposon insertions and deletion of the entire CHM gene [ 17].
In charge was Petty Officer Young, a small, no-nonsense woman with metal-framed glasses and hair pulled back in a tight carceral bun.
For example, Edwin Land, the inventor of the Polaroid camera and confidant of Eisenhower, believed in small, no-nonsense meetings; an automobile provided about the right amount of space.
It is very easy to blame the political class for this small-minded nonsense, but in their lack of ambition they represent a truth of the city.
The room itself was pleasantly decorated and just spacious enough -- with two double beds, two chairs, a table, a minibar with sink, a large closet and a small no-nonsense bathroom.
Therefore she is the first one to crawl, and because of her objectivity, and also because she has what you might call a "swimmer's butt" (small, no-nonsense), she prevents us from attaching narrative meaning to that seemingly narrative action.
Twenty-eight of the mutations we used are presumptive null alleles characterized by small deletions or nonsense substitutions, whereas the other two mutations were previously reported to cause a reduction of function.
Most mutations are private, and those patients presenting both alleles with mutation predicting synthesis of a non-functional protein such as nonsense, small insertions and/or deletions tend to show a more severe phenotype.
In all cases, the mutations were heterozygous sequence changes – missense, nonsense, small deletion/insertion or splice-site mutations – confirming this is predominantly, if not exclusively, an autosomal dominant disorder.
Skowmon Hastanan, in a small, powerful, no-nonsense installation, addresses the issue of Western sexual tourism in Thailand.
