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The silver additive enabled achieving a high antibacterial effect but resulted in a small inhibitory effect of osteoblastic proliferation and differentiation.
In contrast, blockade of N- or R-type Ca2+ channels has only a small inhibitory effect on CSD threshold and velocity of propagation.
This effect is presumably due to a small inhibitory effect of arabinose on the growth rate of E. coli.
However, this relatively small inhibitory effect is unlikely to account for the marked reduction in HIF-1α protein expression observed with both drugs.
A small inhibitory effect of CatL-inh (0.05, 0.5 µM) on OT-II T cell response to OVA was observed although inhibitory effect of CatL-inh at high concentration (5 µM) on the T cell response was found (Figure S1).
In the reciprocal hybrids in a VN background, the PB1 subunit had the most obvious effect causing a decrease in activity (Figure 4A, lane 6) whilst the PB2 subunit had a small inhibitory effect (Figure 4A, lane 7).
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Conversely, blocking N- or R-type Ca2+ channels seems to have only small inhibitory effects on the CSD threshold and velocity of propagation.
These partial and relatively small inhibitory effects on purine and pyrimidine biosynthesis by ferulic acid might help explain the comparatively small but still visible inhibitory effects on C incorporation into downstream dATP, UTP, and dCTP that we described above.
However, we found that caspase activation only partially contributed to the cell death, as two different caspase inhibitors, z-VAD-fmk and Boc-D-fmk, showed small inhibitory effects on the compounds' efficacy but no effect on potency.
These small inhibitory effects of Xestospongins C and D are not sufficient to be useful, and nor are they sufficient to reliably assess whether there is any subtype-selective interaction of Xestospongins with IP3Rs.
It is, therefore, possible that the small inhibitory effects in multiple pathways, that we have described so far, interact resulting in a greater inhibition of platelet response and thrombus formation.
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