Exact(23)
The effect is greater when populations have a small effective size, but generally small or undetectable when effective population size is large a.
In a population with small effective size, the variants with small selection coefficients, particularly slightly deleterious mutations, will act as strictly neutral alleles to drift to higher frequencies and even to reach fixation [45], [46].
Generally, these populations have a small effective size, and are composed of a few families with about a hundred descendants.
In populations with a small effective size, natural selection is less efficient, and hence, the fate of mutations is largely determined by random genetic drift.
The conclusion might then be to use HaploMax for animal populations with a small effective size and having evolved over a few generations.
Second, a small effective size means high confidence of the observed biases and indicates some genetic factors (e.g., CpG effects) that contribute significantly to the biases.
Similar(37)
Then, favorable combinations of polymorphisms will be sought in manageable breeding populations with small effective sizes to trace QTLs by linked markers.
With amounts of data commonly available today (samples of about 50 individuals; 10 20 microsatellite-like loci), quite good precision can be obtained for populations with relatively small effective sizes (about 100 200 or less).
The method provided useful information concerning N e for species with small effective sizes under a variety of life histories and sampling strategies even when generation time was relatively long.
Maternally inherited plastid markers often display stronger differentiation between populations than biparental markers due to their smaller effective size and lack of recombination [ 56, 67- 69].
More outliers were observed in the line with a smaller effective size, an interesting finding considering that selection is expected to be more efficient in larger populations (Wright 1931).
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