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The problem is one of small effect sizes.
There are probably many alleles with small effect sizes.
Studies aiming to improve patient-provider communication also had very small effect sizes.
Interactive systems were rudimentary and not integrated into electronic health records; they exhibited very small effect sizes.
This set of studies had sufficient statistical power to detect small effect sizes.
Indeed, the science behind mindfulness meditation has often suffered from poor research designs and small effect sizes, as 15 psychologists and neuroscientists found after reviewing hundreds of studies.
Cramer's V reveals only small effect sizes (see Table 4).
According to Sitkin, "we tend to too readily dismiss small effect sizes".
Given the small effect sizes for susceptibility alleles, extremely high numbers of people would need to be screened to detect one "high-risk" case.
Due to the small effect sizes, we decided to nevertheless include them in the comparison of the groups.
A few of the studies found statistically significant impacts, but even those found very small effect sizes, and only on some but not other measures or subgroups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com