Exact(25)
Recently, a small duplication covering from ATP10A to GABRB3 was reported in one autism patient [5].
These individuals carry a small duplication of 10 genes including DYRK1A, consistent with a role for DYRK1A as a candidate gene in Down syndrome [3].
Patient p13 had a t (15.17) accompanied by a small duplication of the telomeric part of RARA and of the TOP2A genes (table 5).
Only a small duplication overlapping exon 1 has been reported (Shaikh et al, 2009).
This small duplication most likely resulted from a typical duplication-shadowing event [ 30, 31].
Another novel small duplication (proband 4) was located adjacent to SNRPN, a gene implicated in Prader-Willi syndrome (PWS).
Similar(35)
For small population size and small-scale duplication events, the probability of fixation also gets higher than 1 or close to 1 (fig. 4 B ).
In our simulations, the fixation of duplicate seems unlikely unless it involves small-scale duplication events.
Thus, small-scale duplication events are not covered, but which could also play important roles in the evolution of small molecules, especially for microRNA.
Moreover these duplicate genes have more often arisen through whole-genome rather than small-scale duplication.
As discussed by Maere et al. [11] large scale duplication events may not disrupt stoichiometric balances, while small-scale duplication events likely do.
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