Sentence examples for small deleterious from inspiring English sources

In a large-scale survey of the genomic aberrations of pancreatic cancers, PTEN deletions were not seen, although small deleterious coding mutations were detected [ 26].

This is more likely to occur when the absolute cost of hemizygosity is small (long pathways and weak selection), because increasing wild-type enzyme dose will have small effects on flux and small deleterious effects on fitness.

Furthermore, it is possible that local adaptation involves only weak antagonistic pleiotropy or conditional neutrality, where a beneficial allele in one environment has only small deleterious or neutral effect in other environments.

M1a2 would be the youngest clade with a more recent expansion than the others so that purifying selection has not had enough time to eliminate mutations with small deleterious effects in the coding region.

We found that the deletion of SGF73 has a small deleterious effect in glucose limitation (−3.64% ± 0.62) but has an increased fitness of 24.3% in sulfate limitation, demonstrating that the positive fitness effects of this mutation may be specific to sulfate limitation.

It is interesting to note that amlodipine and verapamil showed the same trend, namely a small deleterious effect in WT mice and a much greater accentuation of growth in Marfan mice, with the effect being greater in the ascending aorta than the aortic root.

Indeed, notches with properly shaped variable tip radii can have a much smaller deleterious influence on fatigue strength, but such optimized notches still are not routinely used in structural design.

All attempts were made to stain sections as fresh as possible, although storage of whole-frozen and cryopreserved brains at −80°C had smaller deleterious effects and LRRK2 signal could be recovered from brains stored at −80°C for several weeks to months.

Thus, this phenomenon is observed only for relatively small recessive deleterious effects, suggesting that it requires some compromise between intense purging and the existence of many sites segregating for deleterious alleles in the base population, so that each individual carries several alleles to be purged and there is on average tight linkage between purged alleles and neutral ones.

It is remarkable that, for small recessive deleterious effects (s = 0.1 and h = 0), this correlation becomes significantly positive even under free recombination.

The manner in which genetic load is purged depends on whether inbreeding depression is due to large or small effect deleterious mutations (Hedrick 1994).