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In general, the numerous small changes arise as a modeling consequence, and are not necessarily data-driven.
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Only small changes arose from increasing the applied pressure or changing the oscillation direction.
Mechanistically, how would those changes arise?
Rainfall changes arise largely through increased temperatures in the ocean.
Further, thermodynamic changes arising from small differences between ligands binding to individual proteins are relatively large and, in general, uncorrelated with changes in solvation, suggesting that trends identified across widely differing proteins are of limited use in explaining or predicting the effects of ligand modifications.
We do not notice these types of large specificity changes arising from small sequence differences in natural PDZ domains, possibly because they disrupt normal PDZ function.
The results can be explained only if the fracture toughness parameters controlling decohesion – e.g. the fracture toughness of the thermally grown oxide and the fracture toughnesses of the interfaces bounding it – are influenced strongly by small changes in composition arising from interdiffusion with the bond coat and underlying substrate, such that they are degraded during thermal cycling.
These distance differences are very small, but potentially of interest since they reflect structure changes arising from changes in electronic structure for the cobaltate layer.
"Small changes are good, big changes bad.
Still, small changes are underway.
Small changes are normal.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com