Small differences were observed regarding wear characteristics (size and morphology), but relevant differences were particularly found in the total number of released particles.
By population-wide comparisons, we identified subtle but relevant differences inaccessible to subjective conceptualization.
Our results in the present study may be considered limited by the relatively small sample size, which could have hidden small but clinically relevant differences in some of the outcome parameters.
In addition, a majority of the studies include small samples, which jeopardises the possibilities of detecting small but clinically relevant differences between groups.
As a result, small, but potentially relevant differences in mask ventilation conditions are difficult to quantify.
However, the study was under-powered to show small but clinically relevant differences.
In accordance with this, selection may well have acted on the perceptual system of the green monkey to enable them to both recognise the small but biologically relevant differences existing between chirps, and perhaps also to form the relevant associations faster whilst experiencing a high level of arousal.
Accounting for the individuals who were lost to follow-up because they developed type 2 diabetes, the statistical power to detect small, but clinically relevant differences in dropout rates between the study groups (Cohen's conventional effect size of 0.1 [ 25]) was 0.835.
Lastly, although the study was powered to detect a difference of 6 points on the SF-36 PCS, the total sample size was relatively small; larger studies are required and should investigate smaller but clinically relevant differences in HRQoL.
Mean QLQ-C30 fatigue scores differed 9.8 points (28.7 vs 18.9), reflecting a small but clinically relevant difference.
