For example, in a small but highly informative proof-of-concept study the combination of the NS5A inhibitor daclatasvir and the protease inhibitor asunaprevir together with PEG-IFN-α and ribavirin for 24 weeks resulted in 100% SVR in HCV genotype 1 patients with prior null-response (Lok et al, 2012).
Ten percent of this cohort had familial/bilateral TGCT, but the number of cancers among relatives was deemed too small for informative analysis.
A variety of small, entertaining, informative, rewarding and surprising gifts.
These empirical results indicate that, when classifying GWA data sets with ts-RF built from small yet informative subspaces, the achieved results can be satisfactory.
This relationship persisted after adjustment for social class (OR 1.60, 1.11 2.33) but was based on small numbers (119 informative pairs, data not shown).
In our experience in marker development using the DNA fingerprinting method MFLP, which is a method based on the combination of the AFLP concept with microsatellite motifs [ 18], we adapted the BSA principle of employing a small number of informative progeny plants, but we kept each individual plant separate in DNA fingerprinting.
The use of different populations in the discovery phase may certainly yield different profiles, but our point was to demonstrate that a small subset of informative genes could provide a significantly prognostic score.
This high probability caused the selection of a small number of informative genes and finally produced a near-optimal subset (a small subset of informative genes with high classification accuracy) for cancer classification.
In this case, there are only a small number of informative samples to be selected, and the random method has a small chance of selecting them.
In general, substructures decreasing bioactivity tend to be small and less informative (e.g. single atoms or substructures with two heavy atoms), than those fostering compound potency.
