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DOI: http://dx.doi.org/10.7554/eLife.05413.011 Close inspection of the time traces occasionally revealed what appeared to be small backwards movements of the attached head, such as the transition starting at 480 ms in the trace of Figure 1A.
We then performed simultaneous tracking of the head and the tail of myosin 5a, which showed that the small backwards transition corresponds to the power stroke of the bound motor domain.
Draw a vertical line, and then to the left of it, draw a small backwards, uppercase D. Letter e: You draw lowercase e with quite a few curves.
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Indeed, it seems to have a small, backwards-pointing gun barrel on it, although closer inspection reveals that, sadly, this is not some device dreamed up by a Swedish Q for wasting couriers with nose rings who take the mickey, but is in fact more prosaic: it's for you keep your pump in.
The resulting traces showed that both the large-scale translocation of the head and the subsequent smaller backwards transition coincide with translation of the tail.
Unlike those who faced the bull and then took small steps backwards, Manolete planted himself before the bull and stayed there.
ON JUNE 18th the Ukrainian crisis, which has slid into a nasty and increasingly bloody civil war of late, took a small step backwards to possible de-escalation.
At the end of the day, sometimes you need to take a small step backwards to take two big steps forward.
In 2014 this trade-off will become more apparent as Western banks in search of stability draw back from foreign markets, dump risky customers and businesses, and refocus on their home base.Globalisation will take more small steps backwards.
"Why wouldn't I write for children?" It was at this point that we both took a small step backwards and excused ourselves before the social awkwardness became too intense, but it was an interaction that stuck with me.
Frustrated, drunk and confused, he kept taking small steps backwards towards the edge of the roof.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com