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The size of the meta-effect lies in between a small and substantial clinically meaningful change.
However, the number of studies is small and substantial differences in study designs and methods exist.
Similar(58)
Overall, the combination of relatively small studies and substantial differences in design and study population led to substantial heterogeneity in reported percentage agreement (inconsistency I2 = 76.4%).
The IR spectrum shows no clear differences between PEG 5 -COOH and PEG 5 -COOHdue to the smand changes and substantial overlaPEG 5 -BP−CH2– and −PEG 5 -BPtions.
This chromosome might be particularly prone to missegregation because of its small size and substantial structural differences between the parental strains [ 31] (Additional file 2: Figure S5).
In most animal species, heritable genetic variation among groups results from limited migration and small group size, and it seems unlikely that these processes can generate sufficient variation among large groups in mammal species with small families and substantial migration between groups.
For these secondary analyses of biologic-naïve patients, and in contrast to the main hypothesis to be examined by CERTAIN, it is likely that the anti-TNF and non anti-TNF groups would not be directly compared to one another given the anticipated small numbers and substantial heterogeneity in biologic-naïve patients initiating non anti-TNF therapy.
43 In addition, the small number and substantial heterogeneity of studies that excluded patients who already had a diagnosis or were receiving treatment did not allow for an assessment of the effect of inclusion and exclusion decisions on diagnostic accuracy estimates.
Get in touch with all the small, silly and substantial things that make you smile.
Although the changes in minute ventilation were small and no substantial change in PaCO2 was observed, an impairment of weight gain and a decrease in body temperature with a concomitant hypoxemia were evident during sustained chest compression.
However, the cisplatin-attributable survival benefit is small and toxicity substantial.
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