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The hepatocytes gathered as colonies and only exhibited small adhesion areas because of the pushing force from proliferating TIG-118 cells.
It is found that a small adhesion parameter results in higher energy dissipation and pull-off force, while a large adhesion parameter leads to lower energy dissipation and pull-off force.
Integrins are cell-surface protein heterodimers that coordinate cellular responses to mechanochemical cues from the extracellular matrix (ECM) and stimulate the assembly of small adhesion complexes, which are the initial sites of cell-ECM adhesion.
These are the most pronounced for small adhesion, where elastic stiffness does not influence the value of the bouncing velocity.
The STM measurement was not possible to be performed on the Pt NP EPD layers before vacuum annealing because of their small adhesion.
We have identified DG as a component of small adhesion puncta during the early stages of myoblast spreading and characterised these puncta as podosomes containing a regulatory complex comprising dystroglycan, Tks5 and Src.
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In an initial stage, Gordts et al. described the presence of small adhesions only upon the ovarian surface covering the early formation of an invaginating small endometrioma identified as a brownish vesicle [25].
This can be explained by the inhibition of maturation of these small adhesions into large ones upon block of contractility as was previously reported in several studies [31], [36], [37].
These fibroblasts then form only small adhesions with the ECM.
In rapidly migrating cells, the rapid turnover of small adhesions in protrusions is highly prominent, whereas less motile cells are populated by larger, more stable adhesions (6).
Analysis of focal adhesion turnover revealed that control cells underwent normal focal adhesion turnover, with small adhesions present at the leading edge, and mature, stable adhesions located farther inside the cell.
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