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Under the small aberration approximations, we give the analytical formula for characterizing the relationship between the sensor signal and the amplitude of the aberration mode.
Similarly, inversions would also be difficult to detect with our methods and a small aberration within the interval may also account for the reduced recombination frequency observed, although inversion breakpoints may have been noted as areas of reduced sequencing coverage because the rearranged DNA would again be categorized as not mapping to the reference genome.
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The older Lightroom was best at erasing small aberrations, like dust spots.
Further, a customized array design can provide comprehensive genomic profiling with additional accuracy in both identifying and defining the extent of small aberrations at target loci.
Small aberrations in the telomeric regions were not taken into account due to chromosomal instability in these regions.
Many small aberrations have emerged as prognostic and predictive markers.
These outliers showed many small aberrations along the genome, and a very large number of breakpoints.
SNP arrays therefore provide the potential for fine mapping of copy number changes, enabling the identification of small aberrations and accurate mapping of chromosomal breakpoints.
Of notice, the few discrepancies measured (both for MLPA and MAQ) could represent very small aberrations, which we anticipate to be very rare.
In general, the same small aberrations as well as large gains were seen in both MIN-Os and tumors, suggesting that these genomic changes were already present in the MIN-Os.
In the integrated analysis, the gene expression levels were normalized per gene by subtracting the average gene expression of a reference sample set consisting of the adenomas with a limited amount of genomic changes (maximum of two small aberrations).
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