Sentence examples for slow rate of internalization from inspiring English sources

Pre-clinical studies have shown a slow rate of internalization of GPC3 targeted with antibody [17, 18].

Thus, the slow rate of receptor internalization cannot be due to impairment in β-arrestin-2 binding to the activated receptor.

This decreased tumor uptake at longer time points is potentially indicative of a slow rate of metabolism and excretion of 89Zr4+ after internalization of HER2/neu-bound 89Zr-DFO-trastuzumab (Figures S4 and S5, and Table S4).

The relatively slow rate of ERBB1 downregulation in response to the PEPDs, compared to that of ERBB2, is likely related to a difference in their internalization and degradation (Yang et al., 2014).

Using flow cytometry to measure the rate of CXCL12/SDF1-induced CXCR4 internalization, we found that WHIM mutant CXCR4 receptors show a slower rate of ligand-induced internalization compared to WT receptor (Figure 2A and B).

Why a slower rate of economic growth?

Since two previous reports demonstrated an association between Tim-1 and CD3, another possible explanation for the enhanced tyrosine phosphorylation in Tim-1 QGQ expressing cells was that Tim-1 QGQ might increase the levels of surface TCR/CD3 and/or slow the rate of TCR/CD3 internalization.

The rate of internalization was further reported to slow down substantially as insulin receptors become saturated, and half-maximal inhibition was observed already at 0.1 nM insulin concentrations; addition of 100 nM insulin reduced the internalization rate to less than 10% [ 48, 49].

Cells depleted of FLNa show a blockage in ligand-induced internalization, while FLNa-deficient M2 cells display a reduced rate of internalization.

At DIV14, we measured the rate of internalization and recycling of pHluorin-GluA1 following NMDA stimulation.

The efficiency and rate of internalization including pharmacokinetics involves complex mechanisms in vivo.