The finding of imprinting in the inbred C57/B6 strain indicates that the differences between fast and slow mice we observed are not genetic in origin, but it remains possible that they reflect variations in gene expression.
Speedy's cousin, the gun-carrying Slowpoke Rodriguez, was the "slowest mouse in Mexico".
Moreover, ASNS inhibition significantly slowed mouse sarcoma growth in vivo only when combined with depletion of plasma asparagine, likely reflecting the ability of systemic asparagine in the tumor environment to replenish intracellular asparagine availability after ASNS inhibition.
CD44s-Separate cells and CD44v7-10 RNAi cells, despite having dramatic anti-growth or pro-chemosensitivity properties in vitro, showed only non-significant trends toward slower mouse subcutaneous xenograft growth.
While eating the pellets, mice were housed individually with water ad libitum and were allowed to eat the pellet for 4 hr or until the pellet was finished, typically a maximum of 6 8 hr for the slowest mice.
Functional interplay between NMNAT-1 and NAD+-dependent enzymes was first suggested by the Wallerian degeneration slow (Wlds) mouse model, a dominant mouse mutation that can significantly delay axon degeneration.
The 'retinal degeneration slow' (rds) mouse (Rd2) is the classical model for retinal degeneration (Sanyal and Bal, 1973) and carries a Prph2 mutation (Travis et al., 1991).
We conclude that this relatively slow growing mouse tumour is capable of rapid morphological adaptation (less than 3 h) to changes in nutrient availability and that oxygen is probably the limiting substrate.
In contrast with human muscles that are composed predominantly of slow myofibres, mouse muscles are mainly fast: such differences between species need to be considered when extending observation from animal models to humans.
In humans, this rate is slow compared mice and to the half-life of 213Bi.
