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The slow induction of the expression of LGR5 by T3 suggests that LGR5 is not directly regulated by T3 via its nuclear receptor at the transcription level.
Conversely, the slow induction of Tlr2 and -9 in parallel with the delayed infiltration of Iba1+/ED1+ cells in the whiskers area of DA rats is associated with susceptibility to HSE.
Thus, T3 regulates the expression of LGR5 during metamorphosis, although the slow induction of the gene in the tail and intestine suggests that LGR5 is not directly regulated by T3 at the transcription level.
The immune responses to FI-MV were characterized by a slow induction of GC formation, low avidity MV-specific IgG with IgG1>IgG2a, high levels of antibody-secreting B cells in the dLNs, and T cells that produced more IL-4 than IFN-γ in response to stimulation with MV.
Currently available methods allow only slow induction of hypothermia (less than 1°C/hour).
In one animal study, a rapid induction of hypercalcemia resulted in a greater CT response than a slow induction of hypercalcemia of similar magnitude [ 35].
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The lower number of identified genes is likely to result from the slower induction of nuclear Nanog in ESΔN-iNanog compared to ESΔN-NERT cells.
In a single-step growth assay (Fig 8a,b), bM24-CMV grew efficiently in Vero cells, with slower kinetics than hrR3 or KOS, presumably reflecting the lower and slower induction of ICP4 by the CMVIE promoter.
Consistent with our hypothesis and the observed slow induction kinetics of CA9, we observed small but insignificant accumulation of 5-hmC at the CA9 TSS by 16 hr of hypoxia, accompanied by an increase of unmodified cytosine at the HRE.
Methoxyflurane is an extremely potent and highly lipid soluble anesthetic agent, characterized by very slow induction (onset of action) and emergence (offset or dissipation) times.
Various attempts to obtain soluble Got1l1, such as alteration of host cells, coexpression with chaperons, cultivation at low temperatures, or slow induction using a low concentration of an inducer, did not increase the solubility of Got1l1.
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