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Provide slow dose escalation to minimise any side effects.
However, in refractory CLL, initial results of ABT-199 treatment have shown potential for tumor lysis syndrome, requiring slow dose escalation.
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TFR was significantly reduced using low starting doses and using slower dose escalations [ 7].
Due to slow recruitment, dose escalation was halted at the 150-mg dose level prior to identification of an OBD, the expansion phase was not initiated, and the study was closed prior to completion.
23 24 29 30 The initial dose in one study was 0.3 mg/kg/day (24), dose escalation was slow (up to 16 weeks) and a 3% incidence of rash was reported.
We explored further dose escalation by slowing infusion rate (2-h) and using premedication (paracetamol).
The rates of dose escalation were much slower (12 19 weeks).
The observation that 29% of tumors were stable after therapy may not necessarily relate to dose escalation, but is likely related to the slow nature of growth of NETs.
Thus, no further dose escalation was performed.
While etanercept had lower dose escalation rates than adalimumab, this is consistent with their labelling which advises against dose escalation.
Design: Randomized, controlled, single-blind phase II dose escalation trial.
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