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Indeed, most Bcl-xL-overexpressing cells experienced mitotic slippage upon prolonged paclitaxel treatment and more than 90% of cells were still alive at the end of the experiment.
Similar(57)
These evidences seem to build upon mitotic slippage, widely considered as the biggest shortcoming of existing antimitotics that is anchored on the basis of mitotic arrest followed by cell death.
Treatment of cells with aneugens might cause mitotic slippage, i.e. upon prolonged activation of the spindle assembly checkpoint, the cells might escape mitosis and re-enter G1 phase, leading to tetraploid mono-nucleated cells with MN instead of binucleated cells in the CBMN assay (Elhajouji et al. 1998; Hashimoto and Todo 2013).
The polysaccharide depolymerization of the middle lamella is one of the major events distinguishing mealy from crispy cultivars, and excessive degradation controlled by the polygalacturonase enzyme determines a significant weakening of the chemical binding between adjacent cells, facilitating cell-to-cell slippage along the middle lamella upon mechanical compression.
The causes of slippage, erosion, or dilation has not been agreed upon by the bariatric surgical community, but a commonly agreed cause is chronic over-adjustment.
By analogy, seismic asperities are defined as patchy areas on a fault surface that prevent slippage during interseismic periods but cause a large slip upon failure (Scholz2002; Okada et al.2005).2005
The resting force measured before and after the activation did not significantly differ, although in some cases it slightly decreased due to a slippage of the ends of the myofibril on the microneedles upon activation.
Consistent with this model, in vitro experiments increasing mitotic slippage protect cells from mitotic cell death, in addition those enhancing survival upon mitotic arrest facilitates mitotic slippage.
There was slippage.
There will be considerable slippage".
How quickly came the slippage.
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Justyna Jupowicz-Kozak
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