Sentence examples for slippage replication from inspiring English sources
This may result in slippage replication of the DNA motif upstream, contributing to the generation and enlargement of BvMSat05 arrays.
Minisatellites are often G/C-rich and fast evolving [ 13] and thought to originate from slippage replication or recombination between short direct repeats [ 16] or slipped-strand mispairing replication at non-contiguous repeats [ 17].
Moreover, DNA sequences that contain palindromic motifs may be linked to slippage replication due to interfering with DNA polymerase during replication and may therefore be involved in the origin of minisatellites.
Tandem repetitive sequences are considered to be generated de novo by the combinatorial action of molecular mechanisms such as mutations, unequal crossing over, gene conversion, slippage replication and/or rolling circle replication [44,67], which create and maintain homogeneity of satDNA sequences within species [65,68].
Strand-slippage replication, also known as slipped-strand mispairing, or DNA slippage occurs during replication of the tandem repeat DNA when there is mispairing between the template and nascent DNA strands (Gemayel et al. 2010).
In addition, organisms might minimize the numbers of tracts in coding regions to avoid the severe, even fatal frame-shift mutations that might be introduced by slippage-replication events at tracts [ 3- 5, 42].
One of the essential genes in this pathway, mutL, includes a short tandem repeat that is prone to polymerase slippage during replication.
However, after in vitro and in vivo passages, such changes were only observed in one of the two genes, implicating another mechanism, and repeat units were possibly deleted through intragenic slippage during replication.
Alternatively, DNA polymerase slippage during replication can also result in spacer deletions (Yosef et al. 2012).
SSRs result from mutations due to DNA-polymerase slippage during replication and unequal recombination [ 5].
A potential mechanism for incorporating runs of similar codons is slippage during replication [ 30].
