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Results of phase two testing demonstrated a relatively consistent slippage pattern across all three participants.
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Blinded analysis of BAT40 without reference to matched normal DNA revealed that all tumours but one (147/148, 99.3%) would have been correctly classified in the absence of normal tissue due to the presence of >2 alleles or to an abnormal pattern of slippage that is not observed with germline DNA.
To identify potential PCR artifacts caused by slippage, we analyzed the patterns obtained from cloned PCR products with those obtained from the samples.
The traditional view attributes this pattern to DNA slippage.
A horn and an anvil tip surfaces were designed with pyramidal patterns to prevent slippage of lap-structured Mg alloy sheets among tool tips during ultrasonic spot welding process.
None of these involve short direct repeats, where replication slippage can readily produce such patterns of homoplasy.
Simple repeat patterns generated by DNA slippage tend to introduce length variations and point mutations in repeat regions.
Therefore, even if a single point mutation event may seem to be the most parsimonious explanation for a repeat pattern variant, a two-step strand slippage event may be more probable.
In this research, possible winding patterns considering the windability and the slippage between fiber and mandrel surface were calculated using the semi-geodesic path algorithm.
In this research, the semi-geodesic path algorithm was used to calculate possible winding patterns taking into account the windability and slippage between the fiber and the mandrel surface.
In order to calculate the winding patterns for non-geodesic filament wound products, the slippage coefficient, which represents the frictional force between the fiber tows and the mandrel surface, was introduced to find the region of possible winding patterns.
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