Sentence examples for slip strand from inspiring English sources

Our data also suggest that tract lengthening via slip strand replication is not governed by a simple thermodynamic loop energy model.

It has been suggested in a previous study that the over-representation occurring around 7 10 bp represented the minimum thermodynamic length required for any simple sequence repeat such as homopolymer tracts to undergo expansion by slip strand replication [ 35].

We believe that these (G+C)% composition dependent variable threshold N values we observed here are describing a complex mechanism that determines successful tract lengthening, rather than a single thermodynamic criterion for successful DNA looping during slip strand replication.

This means that the base composition of the organism is the most important determinant of the particular threshold N value where over-representation begins and argues against an absolute solely thermodynamic determinant to the N value where over-representation begins via slip strand replication.

This result is counter-intuitive to a thermodynamic argument, since the high (G+C)% base composition in neighboring sequences around a short poly dA) tract in a high (G+C)% organism would be expected to resist the tract looping out to allow for slip strand replication because of the higher level of base stacking stabilization energy in the (G+C -rich neiG+C -richsequeneighboring

When the remaining tandem repeated duplexes are subjected to more cycles of denaturing, reannealing and elongation, the number of repeat units increases continuously through slipped strand pairing and DNA polymerase elongation (Fig 1, right).

Gain or loss of tandemly repeated sequences is likely to result from either slipped strand synthesis or recombination events and often has important biological functions, such as length variation in Mycoplasma coat lipoproteins [31].

Due to slipped strand mispairing within the 5'-VNTR region that encodes the poly-ψ-domain, a multitude of NeuO variants can be generated and so far, heptad numbers between 1 and 31 (corresponding to 3 to 93 nucleotide repeats) were observed in naturally occurring isolates [13].

Repeat length differences probably originating from slipped strand mispairing mutagenesis were evident in all strains.

They are caused by slipped strand mispairing during DNA replication [ 24, 25].

Mutations in SSRs are thought to be the result of slipped strand mispairing during DNA replication; slipped strand mispairing can occur because the tertiary structure of SSRs allows mismatching and repeats can be inserted or excised during DNA duplication [ 41- 43].