Yet, interestingly, recent analysis suggests that linear motifs (LMs) (thus not differentiating between ELMs and SLiMs) show high overlap with MoRFs [ 12].
GO Slim category profiles in overlapping and unique sets of Orthogroups within each interface transcriptome were tested for proportionality by a Chi-Square test (Additional file 4: Figure S3A-F).
Third, being located within disordered regions enables overlapping SLiMs to change their conformations to bind to different partners and thus increase signalling complexity.
To determine if the annotation profiles were similar between the overlapping and unique transcriptome components we plotted the proportion of GO Slim categories of unigenes represented by unique or overlapping Orthogroups in Figure 2.
In this network, unlike the original interactome, each node represents a significant GO slim term and each weighted edge indicates the extent of overlap between genesets of their corresponding terms.
CluSTr Slim is a pruned tree of clusters ≤1000 with <90% cluster overlap, which maintains CluSTr's predictive power (Petryszak et al., 2005).
(a) Alignments to the rainbow trout (RBT) genome, BLAST results, gene functions, and gene ontologies (GO Slim Terms) for all mapped loci within the seven genomic regions that exhibited overlap among the three tests of adaptive divergence (Region of Overlap, described in Table 1).
In addition to that, the work proposed in [12] also defines an evaluation metric to measure the overlap among nodes (called fat-factor) and presents an algorithm to reduce this overlap (called Slim-down).
It was slim — really slim.
