This method may not be suitable for SLiMs longer than 10 amino acids, since it assumes that most residues in the SLiM could influence the interaction.
The method may not be suitable for SLiMs longer than 10 amino acids, since it assumes that most residues in the SLiM could influence the interaction.
Here, we exploited the recently developed bimolecular fluorescence complementation (BiFC) (Hudry et al., 2011) to profile a wide range of Hox protein interactions in the Drosophila embryo and investigate whether SLiMs could influence their specificity in vivo.
Those two races are most intriguing – the delegate counts are relatively rich, the margins between each candidate are slim, and the influence they have on the electoral map will be significant this fall.
Beyond stemming a current threat, the Saudis may also be thinking about their long-term influence, Slim said.
He unspools a litany of early influences: Slim Harpo, Lightnin' Slim, Jimmy Reed, the Dixie Hummingbirds, the Five Blind Boys of Alabama, Wynonie Harris, Little Walter, Riley Puckett, and the Staple Singers.
Protein-protein interactions mediated by SLiMs have a widespread influence on cellular functions[ 12, 13].
While the chances of defunding it before then are slim, dramatic opposition now will influence that verdict in several ways.
The monikers Ice-T and Ice Cube nod to the influence of Iceberg Slim, the pimp turned author whose real name was Robert Beck, on the ethos and style of gangster rap.
