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HeLa cells were only slightly sensitized to TRAIL.
In contrast to 5-fluorouracil, p53 siRNA slightly sensitized cells to Taxol, reducing the IC50 from 5.45 to 2.99 nM.
In the current study, Mcl-1 downregulation slightly sensitized Huh7 cells towards co-treatment with TRAIL and 5-FU (50 ng/ml and 150 μg/ml, 24 h, 28.9 vs. 27.4% apoptosis, p < 0.05, Fig. 5C).
In contrary, knockdown of Mcl-1 slightly sensitized HCC cells towards inhibition of mTOR by rapamycin (5 nM, 24 h, p < 0.01), selective inhibition of VEGF (Flk-1) and PDGF receptor tyrosine kinases by SU5614 (15 μM, 24 h, p < 0.01) (Fig. 4) and inhibition of the Raf I kinase (p < 0.05, 100 nM, 24 h, Fig. 5A).
Inhibition of EGF receptor tyrosine kinase activity by AG1478 (5 μM, 24 h), slightly sensitized cells towards Mcl-1 downregulation (p < 0.001, Fig. 5A).
Control siRNA transfection slightly sensitized cells to etoposide-induced cell death (approximately 5%), but did not alter distribution of the phenotypic responses, with about 90% of cells exhibiting pulsing p53 followed by cell-cycle arrest, similar to that of control cells.
Similar(51)
The repeated low-dose re-challenge with TMA in topically sensitized rats resulted in similar or slightly aggravated time-related responses over a period of 7 weeks.
The inhibition of apoptosis sensitized both HepG2 and HepG2-8960-R to X-rays slightly at lower doses and significantly at 10 Gy (Supplementary Figures S2A and B).
Pretreatment with sub-toxic or slightly toxic concentrations of chemotherapeutic agents (cis-diammine dichloroplatinum, CDDP and doxorubicin, DXR) sensitized both cell lines to TRAIL-induced apoptosis, as assessed by the propidium iodide or Annexin V-Cy5 staining method.
They were sensitized.
Imagine if the world were sensitized in this way.
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