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Doxorubicin in combination with anti-Fas antibody had a slightly additive effect on caspase-3 activation.
WT-BMDM treated with IL-4 (50 ng/mL) and TGF β1 (50 ng/mL) increased Arg-I protein in these cells with a slightly additive effect of exogenous galectin-3 (50 μg/mL) in response to IL-4 stimulus (Fig. 5A and B).
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Interestingly, combining est1 ∆ and yku80 -135i mutations had a slightly additive negative effect, with telomeres shorter in the est1 ∆ yku80 -135i strain than in the est1 ∆ strain in the presence of a Cdc13– Est2 fusion.
On the contrary, the reverse sequence (GA followed by CDDP) and the concomitant treatment schedule resulted in a slightly synergistic or additive effect.
The combination of ER stress and osmotic stress promoted a slightly more than additive effect on the accumulation of GmNAC6 transcripts in a fashion similar to the induction of the NRP-A and NRP-B genes.
This suggests a slightly sub-additive effect (DER=0.872 at 2 Gy) in HCT116 p53wt cells treated with PHA680632 before irradiation (again, the survival was normalised to the survival curve control, no irradiation).
This is slightly greater than an additive effect which would have yielded 3% (0.42 × 0.36 × 0.22 = 0.03) of the controls (17+/-13 17+/-13ompared to 560).
The figures would possibly be slightly different if one considered the additive effect of multiples recessive deleterious mutations affecting different genes, each with lower allelic frequencies, and clearly different with different mutation rates.
Also, for C3 an additive effect was seen (p = 0.007), which was slightly weaker than the individual effects of CFH and LOC387715, but still made the overall fit of the three-locus model statistically significantly better than any two-locus models.
At 4 hr, there were slightly synergistic increases in interleukin-1 β and interleukin-6, an additive effect on interleukin-1Ra, and less than additive effects on interleukin-1α and macrophage inhibitory factor.
However, loss of both AtRGS1 and WNK8 (rgs1-2/ wnk8-2) conferred slightly more NaCl tolerance than the rgs1-2 alonee alone suggesting a small additive effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com