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Both parent compounds showed slight toxic effects towards algae Pseudokirchneriella subcapitata and bacteria Vibrio fischeri.
The higher concentrations of the polymer did not seem to have toxic effects on the cells if the excess of PEI remaining in solution was removed thoroughly (slight toxic effects were observed at the 250 μg/ml concentration if the solution was not fully removed after the treatment).
In the present study, treatment with UVA and DPE alone or UVA radiation followed by DPE exposure (data not shown) had slight toxic effects on AL cells, which indicates that DPE might be photosensitized by UVA, leading to an enhancement of cellular and genomic damage in mammalian cells.
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There was no toxicological effect measured by Vibrio fischeri when CSO was disinfected with PFA; a slight toxic effect was observed on CSO disinfected with PAA.
In accordance with this, our regular laboratory examinations carried out over a period of several years following the implantation have never indicated the existence of even the slightest toxic effect in any of our cases.
As it proved so effective, it was adopted as a standard weapon in the first Gulf war despite its slight radioactive content and toxic effects.
In this latter cell line, rotenone exhibited a slight dose-dependent toxic effect.
Yanai et al. [174] PFBS Rats 30 to 1, 000 mg/kg No impairment of fertility or reproduction, no developmental toxic effects aside from a slight delay in onset of puberty, and weight gain in male F1 rats of the group with the highest dosage n.r.r
Previous studies have already tested this pharmacological association in irradiated normal [45] and cancer cells [46], [47] with either toxic effects or only a slight radiosensitizing effect in vitro.
They propose sealing the nanoparticles within a thin shell of silica to minimise any toxic effects.
Toxic effects were not observed.
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