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As evaluated on day 11 (Table 1), the inhibitory effect of 1 mg/kg CDDP was 39.2%, and 10 mg/kg, 20 mg/kg and 40 mg/kg GAP159 showed slight therapeutic efficacy with 10.6%, 18.4% and 33.5% TGI, respectively.
While we were able to demonstrate a slight therapeutic benefit use of phytochemicals in the management of cancer pain, this benefit did not achieve statistical significance, which is a function of both the quality and marginal number of the studies that were acceptable for inclusion in a systematic review.
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The resultant improvement in radiosensitization at low, clinically relevant, concentrations is so slight that any therapeutic benefit would depend on reduced drug toxicity in man.
Both of these effects were dose-dependent and could be induced by all wavelengths between 630 and 1064 nm with slight variations in therapeutic dose-ranges according to the wavelength used.
They found that the rate of inpatient ERCPs dropped from 74.95/100 000 persons in 1996 to 59.70/100 000 in 2002, driven mostly by a decrease in diagnostic procedures, while there was a slight concomitant increase in therapeutic procedures.
This reduction in the strength of the correlation between changes in core symptoms and HR-QoL may indicate a slight detachment from the primary therapeutic effect of atomoxetine on core symptoms, especially when taking into account that atomoxetine showed the highest effect sizes in improving HR-QoL in the Risk Avoidance domain and sub-domains.
15 This trend was influenced by a substantial increase in the rate of therapeutic procedures and a slight decrease in diagnostic procedures.
This holds especially true for drugs with a narrow therapeutic index in which a slight increase in brain concentration leads to a large increase in effect size.
However, the administration of Chinese herbs at large doses usually shows good therapeutic effects with no or slight side effects [ 17].
The other exhibited a clear discrepancy between the pre-treatment 99mTc-MAA SPECT scan and post-therapeutic acquisitions due to a slight difference between injection techniques and an asymmetric arterial flow.
Therapeutic benefit of treatment, ie, at least slight improvement of symptoms, was observed in 176/191 patients (92%) in the OD group and 168/189 (89%) in the TID group.
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