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The ancestor of all CMGC kinases had slight specificity for proline at its +1 site (+1P), and then subsequently evolved broader specificity for both proline and arginine (+1PR) along the lineage leading to mammalian RCK and fungal IME2 kinases.
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These included ETS1 and ETS2, which had slight specificity, and ELK3 and ERG, which showed strong specificity for ERK2.
Second, the specificity for pain remains unclear.
Perhaps the speech will add specificity, for better or worse.
Assembly annotation specificity for single and co-assemblies.
Exploration of the substrate specificity for GRKs and the ligand specificity for arrestins remains in its early stages.
(Like the iPad!) The Nook Color is open to even more apps, but only designed specificity for the device.
Slight non-specificity of S1 nuclease towards dsDNA was observed.
We opted for trypsin as the model system, because this enzyme is highly specific for arginine, in contrast to papain, which exhibits broad substrate specificity, with only a slight preference for arginine.
> -wrap-foot> We can also see that CeePre2 outperforms CeePre1 in terms of almost all metrics except for slight decrease in specificity.
They display broad sequence specificity in degrading polypeptides, with a slight preference for hydrophobic residues at P1 position [ 5].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com