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These included ETS1 and ETS2, which had slight specificity, and ELK3 and ERG, which showed strong specificity for ERK2.
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The ancestor of all CMGC kinases had slight specificity for proline at its +1 site (+1P), and then subsequently evolved broader specificity for both proline and arginine (+1PR) along the lineage leading to mammalian RCK and fungal IME2 kinases.
However, the performance in classifying advanced fibrosis (both raw and cross-validated) was similar to that of the univariate (2D-MRE based only) model, with a slight gain in specificity and total classification accuracy and a slight loss in sensitivity.
The analyses suggest a trend of CURSI and CURASI both showing higher sensitivity with only a slight reduction in specificity, and similar results were seen when comparing CRSI and CRASI to CRB-65.
This led to a slight increase in sensitivity, specificity and LR+ of the assay and a decrease in LR−.
Similarly, unmatched citations that were not detected by a search strategy were included in cell 'd' of the table (Table 7), leading to slight overestimates of the specificity and accuracy of the strategy.
In human colon and colonic cancers, however, C/EBPα can be detected suggesting that there is some species specificity and a slight decrease of expression has been detected in more advanced colon cancer [ 34].
As a conservative approach, unmatched citations that were detected by a given search strategy were included in cell 'b' of the analysis table (Table 7) leading to slight underestimates of the precision, specificity, and accuracy of the search strategy.
What else communicates so much specificity and mystery so concisely?
Hypnosis in surgery: Efficacy, specificity, and utility.
Basis for ligand specificity and regulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com