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The results indicate a slight selectivity for the plasma membrane in the ConA phase: 0.55% of the ALP activity was recovered, compared to 0.37% for both the SDH and CCR activities (Table 1).
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Depsipeptide showed a slight selectivity of about three- to five-fold and apicidin was equally potent against one matched lung cancer/HBEC pair showing no selectivity, but was ∼25-fold specific for cancer in the second pair of lines.
One methyl substituent gives a slight selectivity (1 a and 1 b), which is increased with two methyl substituents (1 c– 1 e), and mesityl salt 1 f gives high selectivity for compound 7.
In LP from cells grown on glucose a slight selectivity seems to occur insofar as more unsaturated PE and PC species accumulated compared to the homogenate.
Though the biological activities found were generally insignificant to poor, two compounds, one of which possesses a reasonable binding affinity for mGAT1, rac-57, the other a notable inhibitory potency at mGAT4, rac-84, both displaying a slight subtype selectivity for the individual transporters, could be identified.
In the case of OYE 2.6, the impacts were more subtle: the Asp mutant showed a significant decrease in stereoselectivity toward cyclohexenone 1 (but not toward alkenes 2 or 3), whereas substituting Ile113 with Trp gave slight R selectivity for 2 (but unchanged stereoselectivity for 1 and 3).
A slight increase in O2/N2 selectivity for the multilayered films was observed over the course of aging.
Selectivity Selective for exogenous CEST agents.
The selected compounds differ in their selectivity for individual transporters.
Selectivity for EB was affected by temperature.
This ensured selectivity for dopaminergic neurons [24].
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