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Taken together the findings suggest that SDH-deficient pituitary adenomas may occur at a young age, may commonly be macroadenomas, may more commonly produce prolactin (on the basis of clinical or IHC findings), and may show a slight male predisposition.
This could be accounted for by genetic predisposition in species, and the slight difference recorded between each cultivar and the wild type could result from minor genetic differences or the impact of other external factors (e.g. growing conditions).
For example, slight changes in allelic expression of the tumor suppressor gene, APC, can affect predisposition to tumorigenesis [4].
Serum fibronectin levels can show a slight but significant increase 3 days before the occurrence of glomerular fibronectin deposits making it a non-specific biomarker for predisposition of FSGS [ 57].
Slight problem.
A slight?
True? – Family predisposition & genetic statement?
McEwan overrides that predisposition almost heroically.
What transforms a predisposition into a disorder?
As with asthma, predisposition and environment conspire.
Should a genetic predisposition influence sentencing?
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