Regarding the use of hydroxyzine during the first trimester, reports concerning a slight higher risk of malformation [ 30] and risk of neonatal seizures in case of use in late pregnancy [ 31] invite cautiousness.
A slight increase in congenital malformations, although not statistically significant, was present in the exposed cohort (1.14, 0.99 to 1.31).
Slight excesses of congenital malformations in the case children and of malignant and benign/borderline neoplastic disease in the older mothers were consistent with the existence of a degree of genetic predisposition in the development of the tumours in this series.
We observed a slight male preponderance of malformations, similar to findings elsewhere (Lary and Paulozzi, 2001; Riley and Halliday, 2008; Bakare et al., 2009), and in keeping with the findings of Lary and Paulozzi (2001), we observed that anomalies of the genitourinary system were more prevalent among boys.
There was a slight increase in fetuses with malformations at 450 mg/kg/day.
When classifying congenital malformations according to the organ system subgroups of EUROCAT, we observed a slight, non-significant, increase in congenital malformations in the vaccinated cohort in most subgroups.
The severity of these malformations varied greatly, from a slight bending to a severe shortening.
Despite the large scale of research, no determined evidence exists to support reproductive hazards related to DBP exposure levels, besides slight correlations with some types of congenital malformations [ 50, 51].
There was evidence of teratogenicity (vertebral malformations) at 400 ppm EGEEA and slight fetotoxicity at 100 ppm; 25 ppm was a no effect level.
Commission Regulation (EC) 2257/94, for example, states that bananas sold in Europe must be "free from malformation or abnormal curvature," though Class 1 bananas can have "slight defects of shape," and Class 2 bananas can have full "defects of shape".
