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It showed a slight dose dependent inhibition which was similar to that on the frequency of mEPSCs.
In sevoflurane groups (1%, exposure lasted 5 hours; 2%, exposure lasted 5 hours; 3% exposure lasted 5 hours), mean frequency of mEPSCs was significantly reduced to 0.510 ± 0.140, 0.438 ± 0.134, and 0.329 ± 0.0765, respectively, when compared to control group (P < 0.05, n = 6, N = 24, Figure 3(b)) and it showed slight dose dependent effects).
In the present study, we found that, 24 hours after sevoflurane exposure, frequency of mEPSC and peak amplitude of calcium current density were reduced in slight dose dependent effects while amplitude of mEPSCs, frequency, and amplitude of sAP were not altered using Drosophila melanogaster whole brain recording model.
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The only relevant immunological findings were very slight dose-dependent changes in interleukin-10 and interferon-γ levels in bronchoalveolar lavage fluid.
In the first paper (Yan et al. 2015a), the authors showed a slight dose-dependent in vitro cytotoxicity to U87MG cells in the range of 0.3 5 mg/mL of DVDMS (Fig. 45b).
A slight dose-dependent character of IFN-γ contents was observed in the 10% pulmonary homogenates (Fig. 6).
A slight dose-dependent relationship was observed for these AEs.
In this latter cell line, rotenone exhibited a slight dose-dependent toxic effect.
Both Med and TRAIL induced a slight dose-dependent decrease in cell viability in myeloid leukemia cells.
Ethanol led to a slight dose-dependent decrease in pHi, with a maximum of -0.069 pH units obtained from 50 mM ethanol, the ethanol concentration for the half-maximum effect on pHi being around 13 mM.
ELISA for IL-6 and IL-1β confirmed a slight, dose-dependent reduction in cytokine production in the media of co-cultures after treatment with CTLA-4-Ig as compared with untreated cells.
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