The agency cautioned parents and health workers to watch for symptoms of overdose, like unusual sleepiness, difficulty being aroused or awakened, confusion or noisy and difficult breathing.
Most common side effects were tiredness, memory problems, sleepiness, difficulty in concentration, unsteadiness.
For sleepiness, difficulty in finding the way, and type of distracting surrounding no significant difference was found.
In severe dengue, an elevated fever might last 2 7 days, and then the patients might develop intense abdominal pain, pallor, clammy and cold skin, agitation, sleepiness, breathing difficulties, a fast and weak pulse, shock and death [ 1].
The researchers at Johns Hopkins found that caffeine withdrawal causes headache, fatigue, sleepiness, and difficulty concentrating.
The REST study reported that RLS sufferers reported daytime sleepiness (32%), difficulty concentrating (15%), and negative influences on daily activities and personal and work life [ 5].
However, negative effects were found in some participants and included symptoms of depression, dry mouth, fatigue, sleepiness, and difficulty with concentration.
Clinical deterioration was defined as appearance of signs of very severe disease such as persistent vomiting (vomiting repeated three times within an hour due to any reason), central cyanosis, grunt, stridor, abnormal sleepiness or difficulty to wake, inability to drink, SpO2 < 85%%, convulsions, or death [ 6].
In addition, daily diaries have been used to track sleep difficulty [ 11], daytime sleepiness and tiredness, difficulty maintaining sleep, early morning awakenings [ 12], sleep disturbance [ 13- 15], and sleep symptoms [ 16].
Daytime sleepiness (DS) involves difficulty maintaining a desired level of wakefulness, i.e., the feeling of drowsiness with a tendency to doze [ 6].
