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Key age-related sleep changes include sleep architecture, sleep regulation through circadian rhythm, sleep latency, sleep duration, sleep consolidation, neuroendocrine function, and sleep pathology.
Mice with NaV1.1 deleted specifically in forebrain interneurons exhibited similar sleep pathology to DS mice, but without changes in circadian rhythm.
I always have a great time teaching others about sleep medicine, both at Duke and at our neighboring VA, whether it is presenting at interdisciplinary rounds, Grand Rounds, or even just explaining various aspects and nuances of sleep pathology to residents and other colleagues.
Future research would benefit from the inclusion of more comprehensive assessments of specific sleep pathology in order to explicate their role in the reported relationship.
Regardless of the presence of FM, our findings were similar to earlier reports of rather low rates of sleep pathology in CFS [ 6, 7].
The aetiology of EDS is multifactorial, particularly among older adults, and has been associated with individual markers of underlying sleep pathology, such as cases of obstructive sleep apnoea (OSA) [ 3].
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We also discuss the implications of these alterations on the neurobiology of HD and the potential to result in hypothalamic, circadian, and sleep pathologies.
An extension of such a hypothesis is that certain sleep pathologies may be related to disruption of such coordinated behavior.
The first night was used to provide accommodation to the study procedure and exclude sleep pathologies.
It is unclear whether as yet-undefined sleep pathologies should be considered as co-morbid features of CFS or as common pathogenic pathways.
Impairment of control over these behaviors leads to the neglect of interpersonal relationships, role obligations, and activities previously important; and often also results in negative health consequences ranging from minor sleep pathologies through obesity and functional somatic symptoms to even suicide [ 14- 20].
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