In addition to the role of Slc1a5/Slc7a5/Slc3a2 in liver growth, other Slc family members that were up-regulated during development may also have roles.
We further inspected those highly DEGs in liver and confirmed that 128 accessions encoding various transporter proteins or solute carrier (SLC) family members, suggesting they were important regulators in response to alkaline stress in liver of L. waleckii.
In contrast to other SLC superfamily members, such as OATs and OCTs that transport hydrophilic anions or smaller cations, respectively, OATPs are characterized by transporting larger amphipathic compounds in a Na+-independent manner (Roth et al. 2012).
Similar to Forde et al. [ 33], Bauersachs et al. [ 29] and Salilew-Wondim et al. [ 31], genes coding metabolite transporters, specifically the solute carrier (SLC) family members were found to be differentially expressed between HF and LF animals.
Another well-characterized SLC family member useful in functional imaging is SLC2A1 (GLUT1), a major glucose membrane transporter that is upregulated in tumor cells (glycolytic rates in tumors can be more than 30-fold higher than in normal cells) [ 11, 12].
Several solute carrier family members (SLC) were down-regulated in the parietal pleura, transporters of multidrug and toxic compounds (SLC47A1), sodium-phosphate (SLC34A2), oligopeptide (SLC15A2), amino acid (SLC6A14), glutamate (SLC1A1), sodium/myo-inositol (SLC5A3) and glucose (SLC5A9) transporters.
In addition, enriched in the category "carboxylic acid transmembrane transporter activity" are 11 SLC gene family members (Table 1).
The SLC transporters include members which function as antiports, where solute movement in one direction is balanced by a solute moving in the reverse direction.
The mRNA expression levels of Slc1a1, Slc6a8, Slc25a15, Slc26a1 [ 13] and the other solute carrier (SLC) gene family members (listed in Table 1) are significantly up-regulated in the enamel organ cells during enamel maturation, and highlight the importance of SLC-mediated chloride-bicarbonate exchange in enamel maturation.
The neighbor network showed two plausible paths for the evolution of SLC to SLL: 1) SLC Ecuador 3, SLC Colombia, SLC Costa Rica, SLC Mesoamerica; and 2) SLC Peru 1, SLC Peru 2, SLC Peru 3 and SLL Mesoamerica.
