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Moreover, it was shown to function in skull development and cause craniosynostosis.
Because Down syndrome involves specific changes to the shape of the skull, and because the genes of skull development are highly conserved between mice and humans, they compared the skulls of these extra-DSCR-containing mice with those of normal mice, as well as with those of mice with the equivalent of trisomy 21.
Most of the sacrifices were of young adults, ten were aged between 15 and 21 years old and eleven were aged little more than 21 years old, based on skull development.
In order to characterize skull development, whole-mount preparations were performed on all of the tadpole stages.
Although this is an indirect measure of brain size, the advantage is that the endocranial cavity does not change with age as long as skull development is complete.
Cranial histology, morphology and computer tomography reveal patterns of internal skull development that show the purported diagnostic characters for the pachycephalosaurids Dracorex hogwartsia and Stygimoloch spinifer are ontogenetically derived features.
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However, cart1 is known to be essential for normal skull bone development, null mice develop with normal limbs and trunk, but the interpatietal and majority of the parietal and frontal bones are absent [65].
It appears that during skull bone development a unique cell type, the 'chondrocyte-like osteoblast' is present [66].
Skull bone development was delayed in hypoxic embryos, with some skeletal defects observed.
(D ) Hypoplasic skull bone development in the Pdgfrb-Cre;Smo flx/flx mutant at P3. Lines indicate the length of skull bones.
Morphologically, rabbits and hares have a more arched skull correlated with development of bounding locomotion and a relatively upright posture of the head.
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