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Reconstructed skin was generated as described before [36].
An additional wavelet model of the skin was generated from the outer surface of the skull, which was obtained using the MNE software extension to the Massachusetts General Hospital's FreeSurfer program.
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Aldehydes in the skin are generated by the oxidation of unsaturated fatty acids released from membrane phospholipids by UV generated ROS.
Type I collagen derived from tilapia (Oreochromis niloticus) scale and porcine skin were generated from Taki chemical, Japan, and Nitta gelatin, Japan, respectively.
Two variants of embryo-aggregated chimeric mice with either variable or no contribution of C57-derived cells to their skin were generated by the fusion of different ratios of morula stage blastomers.
When the dorsal skin wound was generated in mice drinking the NO inhibitor L-NAME, the surface wound was diminished compared with the control group.
Since the skin model was generated using a defined set of parameters, the simulations allow for a precise ground truth of the desired soft tissue thickness.
The new question 'Have you been worried about your skin being yellow?' was generated from HCP interviews, but an equivalent question from the EORTC QoL item bank could not be found.
Most importantly, laminin 5 staining revealed that, just as in normal human skin, a basal lamina was generated to physiologically connect the epidermal to the dermal portion of the artificial skin (lowest panel, Figures 1a and b).
A series of final six propanoyloxy derivatives of 5β-cholan-24-oic acid (tridecafluoroctylsulfanyl- and tridecafluoroctylsulfinylethoxycarbonylpropanoyloxy derivatives) as potential drug absorption promoters (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis.
A thin layer of collagen gel (4.6 mg/ml) containing 50 μg/ml of DQFITC-Collagen I from bovine skin (Life Technologies) and 10% FBS was generated.
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