Thus, zinc cream had a specific effect, namely, reversing the skin-test suppression of zinc deficiency.
UV radiation is a major exogenous toxic agent [9] that leads to cellular damage and effects such as sunburn, immune suppression, skin cancer and photoaging [10].
Biochemical and histological studies revealed that the Protandim diet suppressed tumor promoter-induced oxidative stress (evidenced by reduction of protein carbonyl levels), cell proliferation (evidenced by reduction of skin hyperplasia and suppression of PKC/JNK/Jun pathway), and inflammation (evidenced by reduction of ICAM-1/VCAM-1 expression, NF-κB binding activity, and nuclear p65/p50 levels).
Our results indicate that improvement in skin hydration and suppression of the release of pro-inflammatory cytokines in skin might be the mechanism by which sericin improves UP.
Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression.
The benefits of this treatment apparently result from increases in skin hydration and suppression of pro-inflammatory cytokines, as shown in our earlier study [ 17, 23], thereby resulting in less skin irritation without any allergic reactions.
10 Corticosteroid therapy may be effective, but its use is limited due to its dose- and time-dependent side effects, including risk of adrenal axis suppression, skin atrophy, tachyphylaxis, striae, rosacea-like symptoms, perioral dermatitis, acne, and purpura.
Moreover, the long-term use of corticosteroids can result in a number of side effects, including risk of adrenal axis suppression, skin atrophy, tachyphylaxis, striae, rosacea-like symptoms, perioral dermatitis, acne, and purpura.
Though the reported data are inconsistent, there is increasing evidence that long-term use of high-dose ICS may have systemic side effects such as cataracts, adrenal suppression, skin changes, and osteoporosis [ 29- 31], and attenuate the adaptive immunity of the airways [ 32].
Previous studies have shown that PAF has an important role in UV-induced immune suppression and skin carcinogenesis, in part by suppressing DNA repair.
