Tissue-engineered skin substitute in the field of wound healing is very significant.
Thus the skin substitute with ESCs seemed to be a good equivalent.
The results were compared with the commercial skin substitute IntegraDRT and untreated wounds.
Laser-assisted bioprinting (LaBP) was used to fabricate a fully cellularized skin substitute (Koch et al. 2012).
This study is to constitute a composite skin substitute with epidermal stem cells (ESCs) and fibroblasts on collagen sponge.
Their viability following grafting can be enhanced by seeding the skin substitute with late outgrowth endothelial progenitor cells (EPCs).
Wound healing was accelerated noticeably when applied with this skin substitute seeded with hEGF gene modified HaCaT cells in vivo.
Apligraf an example of a "composite skin graft", "skin equivalent" or "organo-typical skin substitute" as it is composed of both living dermis and epidermis.
At present, there is no skin substitute in the market that can replace all the functions of skin 'and the research is still continuing for a better alternative.
Synthetic skin grafts made from biodegradable polymers have increased the precise controllability of the structure and function of the skin substitute.
In this study we were able to generate a three-layered skin substitute based on a fibrin hydrogel.
